Naproxen-Gelucire Nanoformulations for Improved Solubility and Dissolution Rate of Poorly Water-Soluble Drug Naproxen
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چکیده
منابع مشابه
تاثیر گلوسیر 13/50 بر سرعت آزاد شدن ناپروکسن از پراکندگی های جامد تهیه شده با پلی اتیلن گلیکول 4000
Background and purpose: Solubility behavior of a drug is one of the key determinants of its oral bioavailability. The bioavailability may be enhanced by increasing the solubility and dissolution rate of drug by combining the drug with a hydrophilic carrier. Naproxen is a poor water non-soluble analgesic and anti- inflammatory drug. A possible way of overcoming the naproxen low aqueous solubilit...
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Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...
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ژورنال
عنوان ژورنال: Journal of Drug Design and Medicinal Chemistry
سال: 2017
ISSN: 2472-355X
DOI: 10.11648/j.jddmc.20170306.11